OrthoBio: Specialists in the technologies that help patients heal faster, safer, better.
We build relationships and connecting medical practitioners through out the nation, with the best options in biologic bone growth, cell based therapy, and regenerative medicine.
Our Products
- Isto Biologics
Isto Biologics is an orthobiologics company dedicated to improving patient quality of life by using the science of human biology to advance solutions for spine, orthopedics, and sports medicine.
Built To Concentrate
The MAGELLAN® is an autologous concentration system that delivers concentrated platelets and cells at the point of care.
CONCENTRATE AT THE PUSH OF A BUTTON
Faster Fusion.
Proven Performance.
InQu® is the cell-friendly biosynthetic™ bone graft with proven clinical efficacy leading to faster bone fusion.
CELL FRIENDLY GRAFT DELIVERS BETTER PATIENT OUTCOMES
InQu’s composition of a resorbable polymer, PLGA, integrated with a biologic molecule, hyaluronic acid, creates a biosynthetic scaffold ideal for bone regeneration.
Tailored Resorption Time
PLGA provides a biopolymer scaffold with a resorption profile tailored to match the rate of new bone formation.
Rapid Cell Binding
Hyaluronic acid creates a cell-friendly microenvironment with a favorable pH, allowing InQu to bind up to 78% of MSCs within 20 minutes
Advanced Allograft Technology
Advanced allograft technology that delivers regenerative capacity in a versatile 100% pure human bone graft.
ADVANCED ALLOGRAFT TECHNOLOGY
100% Human Bone
No extraneous carries, fillers or binding agents
Advanced Processing
Enhanced regenerative capacity and handling compared to particulate DBM.
Terminally Sterilized
Provides device level assurance of safety ( 10-6)
Osteoconductive
Three dimensional scaffold providing an optimal environment for cellular attachment and proliferation.
Osteoinductive
Proven regenerative capacity by exhibiting all five elements of new bone formation in a validated animal model.
Room Temp Storage
Ambient storage for convenient distribution and consignment.
Multiple Sizes And Configurations
Cortical Fibers, Strips and DBM Putty available in multiple sizes.
MULTIPLE SIZES AND CONFIGURATIONS FOR EASE-OF-USE IN A VARIETY OF APPLICATIONS
Influx™ Demineralized Cortical Bone Fibers
An advanced allograft that combines the regenerative capacity of interconnected fibers with the availability of growth factors endogenous to cortical bone.
Proprietary Processing
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Proven regenerative capacity in a validated animal model.2
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Increased patient safety through terminal sterilization
Novel Small Diameter Fibers
Fully Automated
Simple one-button start for ease of use
Closed System
Minimal breaks in sterile barrier promote safety
BioAdaptive Processing
Works with optical sensors to tailor processing parameters based on each patient's hematocrit
Optical Sensors
Identify the cellular fraction to eliminate error and optimize results
Selectable Output
Allows users to define desired therapeutic volumes (3-10 mL per cycle)
Unique Formulation
MULTIPLE SIZES AND CONFIGURATIONS FOR EASE-OF-USE IN A VARIETY OF APPLICATIONS
Influx™ Demineralized Bone Matrix Putty
Fully moldable, 100% demineralized bone graft putty offers optimal regenerative capacity through a proprietary processing of demineralized cortical fibers and demineralized cortical particulate.
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Validated to produce a positive osteoinductive response
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Processed for enhanced regenerative capacity compared to particulate DBM
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Maintains moldable, cohesive handling characteristics to fill irregular defects and provide lavage resistance.
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Ready-to-use directly out of packaging with no need for graft preparation or hydration.
Optimal Regenerative Capacity
Ease-of-Use in a Variety of Applications
Sizes and Configurations
Influx™ DBM Fibers
Size 1 cc
Size 2.5 cc
Size 5 cc
Size 10 cc
Influx™ DBM Strip
Size 50 x 10 x 5 mm
Size 50 x 20 x 5 mm
Size 100 x 10 x 5 mm
Size 100 x 20 x 5 mm
Influx™ DBM Putty
Size 1 cc
Size 2.5 cc
Size 5 cc
Size 10 cc
ADVANCED CELL CLEANSING
GROWTH FACTORS
EASE OF USE
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10-Minute Thaw Time In Room Temperature Water Bath
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DMSO Free: Immediately Implantable Upon Thawing In A Ready-To-Use Syringe
CELLULAR BONE MATRIX
Influx™ SPARC is a fully pliable, cellular-enriched allograft with a high concentration of growth factors for use in bone repair or reconstruction.
ADVANCED TECHNOLOGIES SET SPARC APART
FIBERS
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Cortical Fibers Have Undergone A Demineralization Process
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Contribute Highly Conductive, Natural Scaffold For New Bone Generation1
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Proprietary Processing Preserves Osteoprogenitor Cells While Removing Red And White Blood Cells
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Bone-Derived Cells Are Contained In Cancellous Chips
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Cortical Fiber DBM Provides High Quality Osteoinductive Signal2
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Additional Growth Factors Are Preserved From Bone Lining Cells And Retained Within The Final Product
SPARC is an advanced, next generation Cellular Bone Matrix (CBM) that incorporates essential components for new bone development. A key advantage of SPARC is the conserved concentration of signal and cells necessary for bone formation.
SPARC contains growth factors captured from bone lining cells that are typically discarded in washing away the bone stroma of the cancellous bone. Native growth factors that can promote induction, angiogenesis, and scaffold proliferation and integration are found in SPARC and are some key contributors for the formation of bone.3 In the processing phase, these growth factors are preserved and available to contribute signaling for bone growth.
CELLS. SIGNAL. SPARC.
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The goal is to improve patient lives and elevate the standard of care in multiple sectors of healthcare.
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Advanced treatment options for patients with acute and chronic wounds and the health professionals who serve them.
- MiMedx
MiMedx is an industry leader in advanced wound care and a therapeutic biologics company, driven to differentiate and address other areas of unmet need.
What Is AmnioFix?
AmnioFix is a dehydrated human amnion/chorion membrane allograft. The product is available in sheet, fenestrated, and wrap configurations in a variety of sizes to reduce wastage.
Protective Barrier
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A semi-permeable protective barrier that supports the healing cascade
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Protects the wound bed to aid in the development of granulation tissue
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Provides a human biocompatible extracellular matrix
Retains Regulatory Proteins
Product Advantages
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SMR2T™ Technology and patented Purion® processing
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Terminally sterilized for additional level of safety
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Easy to apply
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Room temperature storage
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5-year shelf life
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Compatible with negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBO)
Clinical Use Examples
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Comorbid patients with complex defects or delayed healing
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Debridements, amputations, dehiscence, flaps, decubitus ulcers, trauma, pilonidal cysts, port sites and burns
Product Details
AmnioFix is processed using Purion, a unique patented method for placental-based allografts that is in accordance with the American Association of Tissue Banks (AATB) standards. The product is derived from donated C-sections of live births in the US. The product undergoes active preservation of the extracellular matrix (ECM), regulatory proteins, and removal of blood contaminants via a proprietary cleansing process. For an additional level of safety, the product is terminally sterilized.
AmnioFix is SMR2T Technology (Selective Membrane of Reparative and Reconstructive Tissue) which provides a semi-permeable protective barrier that supports the healing cascade. The product protects the wound bed to aid in the development of granulation tissue and provides a human biocompatible extracellular matrix that retains 300+ regulatory proteins.1-3
1. Koob, et al. J Biomed Mater Res B Appl Biomater. 2014 Aug;102(6):1353-62. 2. Lei, et al. Adv Wound Care. 2017 Feb 1;6(2):43-53. 3. MM-RD-00086, Proteome Characterization of Purion Processed Dehydrated Human Amnion Chorion Membrane (dHACM) and Purion Plus Processed Dehydrated Human Umbilical Cord (dHUC) Allografts.
AmnioCord provides a protective environment to support the healing process. AmnioCord is derived of human umbilical cord. It is a thick graft that allows for suturing to keep the graft in place and works with deep surgical sites.
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Provides a protective environment to support the healing process
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Comprised of an extracellular matrix of hyaluronic acid and collagen
Retains Regulatory Proteins
Product Advantages
-
SMR2T™ Technology and patented Purion® processing
-
Terminally sterilized for additional level of safety
-
Easy to apply
-
Room temperature storage
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5-year shelf life
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Compatible with negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBO)
Clinical Use Examples
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Comorbid patients with complex defects or delayed healing
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Smaller or deeper surgical sites
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Tendon, bone, or hardware coverage
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Diabetic Foot ulcers (DFUs), venous leg ulcers (VLUs), or decubitus ulcers
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Debridements, amputations, dehiscence, flaps and trauma
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When graft fixation is desired
Product Details
AmnioCord is processed using Purion, a unique patented method for placental-based allografts that is in accordance with the American Association of Tissue Banks (AATB) standards. The product is derived from donated C-sections of live births in the US. The product undergoes active preservation of the extracellular matrix (ECM), regulatory proteins, and removal of blood contaminants via a proprietary cleansing process. For an additional level of safety, the product is terminally sterilized. AmnioCord is SMR2T Technology (Selective Membrane of Reparative and Reconstructive Tissue) which provides a semi-permeable protective barrier that supports the healing cascade. It protects the wound bed to aid in the development of granulation tissue and provides a human biocompatible extracellular matrix that retains 250+ regulatory proteins.1,2
1. MM-RD-00086, Proteome Characterization of PURION Processed Dehydrated Human Amnion Chorion Membrane (dHACM) and PURION PLUS Processed Dehydrated Human Umbilical Cord (dHUC) Allografts. 2. Bullard, et al. J Biomed Mater Res B Appl Biomater. 2019 May;107(4):1035-1046.
What Is AmnioCord?
Protective Environment
What Is EpiFix?
EpiFix is a dehydrated human amnion/chorion membrane allograft. The product is available in sheet configurations in a variety of sizes to reduce wastage.
Protective Barrier
-
A semi-permeable protective barrier that supports the healing cascade
-
Protects the wound bed to aid in the development of granulation tissue
-
Provides a human biocompatible extracellular matrix
Retains Regulatory Proteins
-
300+ regulatory proteins1-3
Product Advantages
-
SMR2T™ Technology and patented Purion® processing
-
Terminally sterilized for additional level of safety
-
Easy to apply
-
Room temperature storage
-
5-year shelf life
-
Compatible with negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBO)
Clinical Uses Examples
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Comorbid patients with complex defects or delayed healing
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Diabetic foot ulcers (DFUs)
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Venous leg ulcers (VLUs)
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Debridements
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Decubitus ulcers
Product Details
EpiFix is processed using Purion, a unique patented method for placental-based allografts that is in accordance with the American Association of Tissue Banks (AATB) standards. The product is derived from donated C-sections of live births in the US. The product undergoes active preservation of the extracellular matrix (ECM), regulatory proteins, and removal of blood contaminants via a proprietary cleansing process. For an additional level of safety, the product is terminally sterilized.
EpiFix is SMR2T Technology (Selective Membrane of Reparative and Reconstructive Tissue) which provides a semi-permeable protective barrier that supports the healing cascade. The product protects the wound bed to aid in the development of granulation tissue and provides a human biocompatible extracellular matrix that retains 300+ regulatory proteins.1-3
1. Koob, et al. J Biomed Mater Res B Appl Biomater. 2014 Aug;102(6):1353-62. 2. Lei, et al. Adv Wound Care. 2017 Feb 1;6(2):43-53. 3. MM-RD-00086, Proteome Characterization of Purion Processed Dehydrated Human Amnion Chorion Membrane (dHACM) and Purion Plus Processed Dehydrated Human Umbilical Cord (dHUC) Allografts.
Contact us for more information about EpiFix
EpiCord is a thick graft that allows for suturing to keep the graft in place and provides a protective environment to support the healing process. EpiCord is derived of human umbilical cord.
EpiCord is derived of human umbilical cord. EpiCord Expandable expands to twice its size and conforms to uneven surfaces and deeper wounds.
Protective Environment
-
Provides a protective environment to support the healing process
-
Comprised of an extracellular matrix of hyaluronic acid and collagen
Retains Regulatory Proteins
250+ regulatory proteins1, 2
Product Advantages
-
SMR2T™ Technology and patented Purion® processing
-
Terminally sterilized for additional level of safety
-
Easy to apply
-
Room temperature storage
-
5-year shelf life
-
Compatible with negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBO)
Clinical Use Examples
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Smaller, deeper wounds or surgical sites
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When graft fixation is desired
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Conforms to uneven surfaces (EpiCord Expandable)
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2 cm x 3 cm expands to 12 cm2 (EpiCord Expandable)
Product Details
EpiCord is processed using Purion, a unique patented method for placental-based allografts that is in accordance with the American Association of Tissue Banks (AATB) standards. The product is derived from donated C-sections of live births in the US. The product undergoes active preservation of the extracellular matrix (ECM), regulatory proteins, and removal of blood contaminants via a proprietary cleansing process. For an additional level of safety, the product is terminally sterilized.
EpiCord is SMR2T Technology (Selective Membrane of Reparative and Reconstructive Tissue) which provides a semi-permeable protective barrier that supports the healing cascade. It protects the wound bed to aid in the development of granulation tissue and provides a human biocompatible extracellular matrix that retains 250+ regulatory proteins.1,2
1. MM-RD-00086, Proteome Characterization of PURION Processed Dehydrated Human Amnion Chorion Membrane (dHACM) and PURION PLUS Processed Dehydrated Human Umbilical Cord (dHUC) Allografts. 2. Bullard, et al. J Biomed Mater Res B Appl Biomater. 2019 May;107(4):1035-1046.
Contact us for more information about EpiCord
What Is EpiCord?
